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Ans. is 'b' i.e., Spongiform change in brain
o The classic histologic appearance in Creutzfeldt-Jakob disease is
spongiform change in the gray matter : in all six cortical layers in the
cerebral cortex or with diffuse involvement of the cerebellar
molecular layer. These vacuoles appear glassy or eosinophilic and
may coalesce. Neuronal loss and gliosis are also seen.
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