💢 The Influence of GLP-1 Receptor Agonists on Five-Year Mortality in Colon Cancer Patients

This scientific article reports on an observational study from UC San Diego suggesting that GLP-1 receptor agonists, commonly sold as Ozempic and Wegovy, may dramatically improve survival rates for colon cancer patients.

The research analyzed medical records and found that colon cancer patients using these drugs, originally developed for diabetes and weight loss, had less than half the mortality rate of non-users.

Researchers speculate that the drugs' anti-inflammatory and metabolic effects, particularly in patients with obesity, may contribute to this benefit.

However, the authors caution that these are only observational findings and emphasize the need for randomized clinical trials to definitively prove that GLP-1 medications directly enhance cancer survival.


🆔 @InternalMed
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Does consumption of caffeinated coffee have a beneficial, detrimental, or neutral effect on the risk of recurrent atrial fibrillation (AF) episodes?

Findings  In this multicenter randomized clinical trial including 200 patients with persistent AF undergoing cardioversion, the risk of recurrent AF was significantly lower in the group allocated to coffee consumption (47%) compared with the abstinence group (64%).

Meaning  Consumption of coffee and other caffeinated products may be reasonably considered in patients with AF.


🆔 @InternalMed
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💢 Eating breakfast later in the day is linked to higher risks of illness and death in older adults.

A recent study found that *delaying breakfast until after 9 a.m.* was associated with a significantly increased risk of cardiovascular disease and all-cause mortality among adults aged 65 and older. Key findings include:

- Early breakfast eaters (before 8 a.m.) had the *lowest risk* of developing heart disease and dying from any cause.
- Those who ate breakfast after 9 a.m. had a 44% higher risk of cardiovascular disease and a 28% higher risk of all-cause mortality.
- The study adjusted for lifestyle factors such as sleep duration, physical activity, and diet quality, suggesting that *meal timing itself* may play a role in health outcomes.

Researchers hypothesize that earlier eating may better align with circadian rhythms, improving metabolic health and reducing inflammation. This adds to growing evidence that meal timing—not just meal content—matters for longevity and disease prevention.


🆔 @InternalMed
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New meta-analysis of 55 RCTs shows GLP-1RAs increase the risk of gallstones and acid reflux—but not other serious GI or biliary events.

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https://ow.ly/zwew50XlXqc


🆔 @GIJournalClub
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Effective management of metabolic dysfunction–associated steatotic liver disease (MASLD) and sarcopenia requires an integrated approach combining diet and physical activity.

The Mediterranean diet is recommended for MASLD due to its benefits on liver and metabolic health. Traditional calorie-restricted diets (low-carb, high-carb, or low-fat) show inconsistent results, while time-restricted eating, alternate-day fasting, and the 5:2 diet show promise but need stronger evidence.

For sarcopenia, increased protein intake and a structured exercise regimen—combining aerobic and resistance training—are crucial for muscle preservation, metabolic improvement, and reducing liver fat.

Currently, no pharmacological treatments target both MASLD and sarcopenia. Bariatric surgery may help patients with MASLD and severe metabolic dysfunction but lacks robust data confirming safety and efficacy in sarcopenia.

📎 Link


🆔 @GIJournalClub
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A systematic review of 1.1M+ patients

Combining SGLT2 inhibitors + GLP-1 RAs may cut risk of death, heart failure & kidney events more than either drug alone 💊💉

📉 MACE ↓ 44%
⚰️ CV death ↓ 74%
🏥 HF hospitalisation ↓ 33%
🧠 All-cause death ↓ 50%
🧬 Kidney events ↓ 52%

👀 Studies were observational, so RCTs needed!

No ⬆️ differences of severe hypoglycaemia, diabetic ketoacidosis, genitourinary infections or gastrointestinal side effects


🆔 @InternalMed
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💢 Taking Melatonin Could Raise Your Risk of Heart Failure, Study Finds

https://www.healthline.com/health-news/long-term-melatonin-use-heart-failure-risk


🆔 @InternalMed
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