🆔 @InternalMed
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A 15-year-old girl with acne vulgaris developed a painful, blistering rash on both hands after starting oral doxycycline. She had frequent sun exposure while playing outdoors without protection. Exam revealed erythematous plaques with vesicles on sun-exposed areas—especially the dorsal thumbs and dorsolateral index fingers—suggestive of doxycycline-induced phototoxicity, a dose-dependent reaction. These specific locations are commonly affected due to direct sun exposure, making them key diagnostic clues. Doxycycline was discontinued, and topical clobetasol initiated. The rash resolved within days, highlighting the importance of recognizing phototoxic patterns and managing with drug cessation and anti-inflammatory therapy.


🆔 @InternalMed
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💢 Too Little Sleep Can Lead to Too Much Weight: What to Do?

https://www.medscape.com/viewarticle/too-little-sleep-can-lead-too-much-weight-what-do-2025a1000pp9?src=rss


🆔 @InternalMed
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🆔 @GIJournalClub
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A 65-year-old man presented with a 4-month rash, 2-month diarrhea, and weight loss. Exam showed a maculopapular eruption on trunk, arms, and legs [A]. Labs revealed normocytic anemia and elevated serum tryptase (>200 μg/L; normal
Immunohistochemistry was positive for CD25 and CD117 (c-Kit). Molecular testing detected the KIT D816V gain-of-function mutation. Findings established systemic mastocytosis, a disorder with mast-cell infiltration of organs including bone marrow, GI tract, and bone. Patient was treated with antihistamines and midostaurin, a c-Kit inhibitor. At 1-year follow-up, symptoms had resolved.


🆔 @InternalMed
.

🆔 @InternalMed
.