💫Drugs that can induce Syndrome of Inappropriate Antidiuretic Hormone (SIADH)👇
Tricyclic antidepressants (e.g amitriptyline, imipramine)
Selective serotonin reuptake inhibitors (e.g., fluoxetine sertraline, paroxetine)
Increased hypothalamic production of antidiuretic hormone (ADH)
Monoamine oxidase inhibitors
Phenothiazines (e.g. thioridazine, trifluoperazine)
Butyrophenones (e.g. haloperidol)
Antiepileptics (e.g., carbamazepine, oxcarbazepine, valproic acid)
Antineoplastic agents (e.g vincristine, vinblastine, cisplatin, carboplatin, cyclophosphamide,
ifosfamide, methotrexate)
💫DRUG MECHANISM previous drugs 👆
💦Increased hypothalamic production
of antidiuretic hormone (ADH)
Opiates Antiepileptics (e.g carbamazepine, lamotrigine)
Potentiation of ADH
Antidiabetics (e.g chlorpropamide, tolbutamide)
Antineoplastic (e.g cyclophosphamide)
Nonsteroidal anti-inflammatory agents
💫Drug mechanism for previous drugs 👆
💦Potentiation of ADH
💫Treatment 👇
💦Once serum Na 145 mEq/L decrease D5W to 1 mL/
kg/h until serum Na 140 mEq/L
💦Central diabetes insipidus👇
💥add desmopressin 👇
💦Initial therapy: 5 to 10 mcg of the nasal spray every
night (qhs)
💦0.1 or 0.2 mg tablet qhs (may result in inadequate
response)
💦1 mcg subcutaneous q12h (if intranasal or oral route
not feasible)
💦2 mcg IV q12h (if inadequate response to subcutaneous)
المرجع
ICU quick drug guide
إعداد قناة طوارئ وعناية مركزة
https://t.me/+I8rrjfkEHkhkYmQ0
https://t.me/Emergency_intensivecare